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COMMUNITY REFERENCE LABORATORY – ANTIMICROBIAL RESISTANCE
 
 
 
Dik Mevius, DVM, PhD, Specialist Veterinary Microbiology
 
Dik Mevius, DVM, PhD, Specialist Veterinary Microbiology
Senior Scientist
Central Institute for Animal Disease Control – Lelystad
P.O.Box 2004
8203 AB Lelystad
The Netherlands

0031 320 238413
0031 320 238153 (fax)
 
 
Competences
 
In 2002 my laboratory became part of the statutory tasks institute CIDC-Lelystad and responsible for the Monitoring Programme of Resistance in Animal Bacteria in The Netherlands.
 
Since May 2003 I am Chairman of the Dutch Working Party that coordinates monitoring of resistance in animal bacteria, VANTURES (Veterinary Antimicrobial Usage and Resistance Surveillance) in The Netherlands. In the program we monitor the emergence and trends in resistance in commensal gut flora of animals and food borne pathogens isolated from animals and humans. The first report (MARAN-2002) was officially presented to the ministries of public health and agriculture on the 16 th of January 2004 and since then published annually.
 
Our laboratory is the Dutch National Reference Laboratory for Antimicrobial Resistance in Animals in The Netherlands.
 
Our research is aimed at characterisation and transmission of multidrug resistance (MDR) in Enterobacteriaceae. We study the contribution of integrons and plasmids to the occurrence and spread of MDR in Salmonella and E. coli from different sources.
 
We have a special interest in ESBLs and plasmid mediated quinolone resistance.
 
I am as National Expert member of the Committee for Veterinary Medicinal Products (CVMPs) Scientific Advisory Group on Antimicrobial Resistance (SAGAM) at the European Medicine Evaluation Agency in London, and participate in advises on licensing of antibiotics in veterinary practice since 1998.
 
My Laboratory has been actively involved in the organization of external quality control programmes for susceptibility tests performed by National Salmonella Reference laboratories and Veterinary Reference Laboratories in the EU in cooperation with RIVM-Bilthoven and DFVF (now namen FOOD.DTU) in Copenhagen.
 
I chair the informal Expert Group VETCAST, which in collaboration with Gunnar Kahlmeter (EUCAST) defines Wild Type MIC distributions for animal bacteria of relevance.
 
I am a member of the EFSA working group on developing harmonized schemes for monitoring antimicrobial resistance in zoonotic agents for the EU-zoonoses reportage.
 
 

Presentations of relevance:

  • Results Ring Trial X – 2005: antibiotic resistance. Community Reference Laboratory Workshop Bilthoven The Netherlands, April 2005
  • Susceptibility testing of Campylobacter spp. Presentation at International Campylobacter Training Course organised by J. Wagenaar as OIE ref lab. April 2006
  • VETCAST. presentation at General Meeting of Eucast at ECCMID in Nice, May 2006
  • ESBLs. Presentation at the MedvetNet workshop on food microbiology in Warsaw, February 2006
     

 

References (1-16) since 2002

  1. Box, A. T., D. J. Mevius, P. Schellen, J. Verhoef, and A. C. Fluit. 2005. Integrons in Escherichia coli from food-producing animals in The Netherlands. Microb Drug Resist 11:53-7.
  2. Hasman, H., D. Mevius, K. Veldman, I. Olesen, and F. M. Aarestrup. 2005. {beta}-Lactamases among extended-spectrum {beta}-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in The Netherlands. J Antimicrob Chemother 56:115-21.
  3. Landman, W. J., K. T. Veldman, D. J. Mevius, and J. H. van Eck. 2003. Investigations of Enterococcus faecalis-induced bacteraemia in brown layer pullets through different inoculation routes in relation to the production of arthritis. Avian Pathol 32:463-71.
  4. Lo Fo Wong, D. M., R. S. Hendriksen, D. J. Mevius, K. T. Veldman, and F. M. Aarestrup. 2006. External quality assurance system for antibiotic resistance in bacteria of animal origin in Europe (ARBAO-II), 2003. Vet Microbiol.
  5. Mevius, D. 2002. [Veterinary antibiotic legislation in jeopardy?]. Tijdschr Diergeneeskd 127:633-4.
  6. Mevius, D. J. 2002. [Standpoint of the Working Group for Veterinary Antibiotic Use requests good use of quinolones]. Tijdschr Diergeneeskd 127:622-4.
  7. Pellicaan, C. H., and D. J. Mevius. 2004. [FIDIN antibiotics report: a comment]. Tijdschr Diergeneeskd 129:533-4.
  8. Steentjes, A., K. T. Veldman, D. J. Mevius, and W. J. Landman. 2002. Molecular epidemiology of unilateral amyloid arthropathy in broiler breeders associated with Enterococcus faecalis. Avian Pathol 31:31-9.
  9. Stegeman, J. A., J. C. Vernooij, O. A. Khalifa, J. Van den Broek, and D. J. Mevius. 2006. Establishing the change in antibiotic resistance of Enterococcus faecium strains isolated from Dutch broilers by logistic regression and survival analysis. Prev Vet Med.
  10. van Boven, M., K. T. Veldman, M. C. de Jong, and D. J. Mevius. 2003. Rapid selection of quinolone resistance in Campylobacter jejuni but not in Escherichia coli in individually housed broilers. J Antimicrob Chemother 52:719-23.
  11. van der Straaten, T., R. Janssen, D. J. Mevius, and J. T. van Dissel. 2004. Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium. Antimicrob Agents Chemother 48:2292-4.
  12. van Pelt, W., D. J. Mevius, H. Stoelhorst, S. Kovats, A. W. Van De Giessen, W. Wannet, and Y. Duynhoven. 2004. A large increase of Salmonella infections in 2003 in the Netherlands: hot summer or side effect of the avian influenza outbreak? Euro Surveill 9 .
  13. van Pelt, W., H. van der Zee, W. J. Wannet, A. W. van de Giessen, D. J. Mevius, N. M. Bolder, R. E. Komijn, and Y. T. van Duynhoven. 2002. [Explosive increase in Salmonella java in poultry. Consequences for public health]. Tijdschr Diergeneeskd 127:625-9.
  14. van Pelt, W., H. van der Zee, W. J. Wannet, A. W. van de Giessen, D. J. Mevius, N. M. Bolder, R. E. Komijn, and Y. T. van Duynhoven. 2003. Explosive increase of Salmonella Java in poultry in the Netherlands: consequences for public health. Euro Surveill 8:31-5.
  15. Waldenstrom, J., D. Mevius, K. Veldman, T. Broman, D. Hasselquist, and B. Olsen. 2005. Antimicrobial resistance profiles of Campylobacter jejuni isolates from wild birds in Sweden. Appl Environ Microbiol 71:2438-41.
  16. Wisselink, H. J., K. T. Veldman, C. Van den Eede, S. A. Salmon, and D. J. Mevius. 2006. Quantitative susceptibility of Streptococcus suis strains isolated from diseased pigs in seven European countries to antimicrobial agents licensed in veterinary medicine. Vet Microbiol 113:73-82.